diff --git a/Cargo.lock b/Cargo.lock
index 91a5c213c..6b0a535dc 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -5380,6 +5380,7 @@ dependencies = [
  "bytecheck",
  "fs-err",
  "futures",
+ "h2",
  "html-escape",
  "http",
  "http-body-util",
diff --git a/crates/uv-client/Cargo.toml b/crates/uv-client/Cargo.toml
index e1a933241..73409d6aa 100644
--- a/crates/uv-client/Cargo.toml
+++ b/crates/uv-client/Cargo.toml
@@ -38,6 +38,7 @@ async_zip = { workspace = true }
 bytecheck = { workspace = true }
 fs-err = { workspace = true, features = ["tokio"] }
 futures = { workspace = true }
+h2 = { workspace = true }
 html-escape = { workspace = true }
 http = { workspace = true }
 itertools = { workspace = true }
diff --git a/crates/uv-client/src/base_client.rs b/crates/uv-client/src/base_client.rs
index 20ef8f7b6..0e4942f78 100644
--- a/crates/uv-client/src/base_client.rs
+++ b/crates/uv-client/src/base_client.rs
@@ -983,7 +983,7 @@ impl RetryableStrategy for UvRetryableStrategy {
 /// Whether the error looks like a network error that should be retried.
 ///
 /// There are two cases that the default retry strategy is missing:
-/// * Inside the reqwest middleware error is an `io::Error` such as a broken pipe
+/// * Inside the reqwest or reqwest-middleware error is an `io::Error` such as a broken pipe
 /// * When streaming a response, a reqwest error may be hidden several layers behind errors
 ///   of different crates processing the stream, including `io::Error` layers.
 pub fn is_transient_network_error(err: &(dyn Error + 'static)) -> bool {
@@ -1027,7 +1027,12 @@ pub fn is_transient_network_error(err: &(dyn Error + 'static)) -> bool {
             }
 
             trace!("Cannot retry nested reqwest error");
-        } else if let Some(io_err) = source.downcast_ref::<io::Error>() {
+        } else if let Some(io_err) = source.downcast_ref::<io::Error>().or_else(|| {
+            // h2 may hide an IO error inside.
+            source
+                .downcast_ref::<h2::Error>()
+                .and_then(|err| err.get_io())
+        }) {
             has_known_error = true;
             let retryable_io_err_kinds = [
                 // https://github.com/astral-sh/uv/issues/12054