diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index feaa38210..459495600 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -266,7 +266,7 @@ jobs:
     timeout-minutes: 15
     needs: determine_changes
     if: ${{ !contains(github.event.pull_request.labels.*.name, 'no-test') && (needs.determine_changes.outputs.code == 'true' || github.ref == 'refs/heads/main') }}
-    runs-on: github-windows-2025-x86_64-16
+    runs-on: depot-windows-2022-16
     name: "cargo test | windows"
     steps:
       - uses: actions/checkout@11bd71901bbe5b1630ceea73d27597364c9af683 # v4.2.2
diff --git a/.github/workflows/setup-dev-drive.ps1 b/.github/workflows/setup-dev-drive.ps1
index e0e2a765b..e003cc359 100644
--- a/.github/workflows/setup-dev-drive.ps1
+++ b/.github/workflows/setup-dev-drive.ps1
@@ -1,13 +1,43 @@
 # Configures a drive for testing in CI.
+#
+# When using standard GitHub Actions runners, a `D:` drive is present and has
+# similar or better performance characteristics than a ReFS dev drive. Sometimes
+# using a larger runner is still more performant (e.g., when running the test
+# suite) and we need to create a dev drive. This script automatically configures
+# the appropriate drive.
+#
+# When using GitHub Actions' "larger runners", the `D:` drive is not present and
+# we create a DevDrive mount on `C:`. This is purported to be more performant
+# than an ReFS drive, though we did not see a change when we switched over.
+#
+# When using Depot runners, the underling infrastructure is EC2, which does not
+# support Hyper-V. The `New-VHD` commandlet only works with Hyper-V, but we can
+# create a ReFS drive using `diskpart` and `format` directory. We cannot use a
+# DevDrive, as that also requires Hyper-V. The Depot runners use `D:` already,
+# so we must check if it's a Depot runner first, and we use `V:` as the target
+# instead.
 
-# When not using a GitHub Actions "larger runner", the `D:` drive is present and
-# has similar or better performance characteristics than a ReFS dev drive.
-# Sometimes using a larger runner is still more performant (e.g., when running
-# the test suite) and we need to create a dev drive. This script automatically
-# configures the appropriate drive.
 
-# Note we use `Get-PSDrive` is not sufficient because the drive letter is assigned.
-if (Test-Path "D:\") {
+if ($env:DEPOT_RUNNER -eq "1") {
+    Write-Output "DEPOT_RUNNER detected, setting up custom dev drive..."
+
+    # Create VHD and configure drive using diskpart
+    $vhdPath = "C:\uv_dev_drive.vhdx"
+    @"
+create vdisk file="$vhdPath" maximum=20480 type=expandable
+attach vdisk
+create partition primary
+active
+assign letter=V
+"@ | diskpart
+
+    # Format the drive as ReFS
+    format V: /fs:ReFS /q /y
+    $Drive = "V:"
+
+    Write-Output "Custom dev drive created at $Drive"
+} elseif (Test-Path "D:\") {
+	# Note `Get-PSDrive` is not sufficient because the drive letter is assigned.
     Write-Output "Using existing drive at D:"
     $Drive = "D:"
 } else {
@@ -61,4 +91,3 @@ Write-Output `
 	"UV_WORKSPACE=$($Drive)/uv" `
 	"PATH=$($Drive)/.cargo/bin;$env:PATH" `
 	>> $env:GITHUB_ENV
-