diff --git a/crates/uv-python/src/discovery.rs b/crates/uv-python/src/discovery.rs
index 67f8f37ff..c067082dd 100644
--- a/crates/uv-python/src/discovery.rs
+++ b/crates/uv-python/src/discovery.rs
@@ -884,6 +884,14 @@ impl Error {
                     );
                     false
                 }
+                #[cfg(windows)]
+                InterpreterError::CorruptWindowsPackage { path, err } => {
+                    debug!(
+                        "Skipping bad interpreter at {} from {source}: {err}",
+                        path.display()
+                    );
+                    false
+                }
                 InterpreterError::NotFound(path)
                 | InterpreterError::BrokenSymlink(BrokenSymlink { path, .. }) => {
                     // If the interpreter is from an active, valid virtual environment, we should
diff --git a/crates/uv-python/src/interpreter.rs b/crates/uv-python/src/interpreter.rs
index 0f074ebb6..fc5adb833 100644
--- a/crates/uv-python/src/interpreter.rs
+++ b/crates/uv-python/src/interpreter.rs
@@ -34,6 +34,9 @@ use crate::{
     VirtualEnvironment,
 };
 
+#[cfg(windows)]
+use windows_sys::Win32::Foundation::{APPMODEL_ERROR_NO_PACKAGE, ERROR_CANT_ACCESS_FILE};
+
 /// A Python executable and its associated platform markers.
 #[derive(Debug, Clone)]
 pub struct Interpreter {
@@ -760,6 +763,13 @@ pub enum Error {
         #[source]
         err: io::Error,
     },
+    #[cfg(windows)]
+    #[error("Failed to query Python interpreter at `{path}`")]
+    CorruptWindowsPackage {
+        path: PathBuf,
+        #[source]
+        err: io::Error,
+    },
     #[error("{0}")]
     UnexpectedResponse(UnexpectedResponseError),
     #[error("{0}")]
@@ -872,10 +882,23 @@ impl InterpreterInfo {
             .arg("-c")
             .arg(script)
             .output()
-            .map_err(|err| Error::SpawnFailed {
-                path: interpreter.to_path_buf(),
-                err,
-            })?;
+            .map_err(
+                |err| match err.raw_os_error().and_then(|code| u32::try_from(code).ok()) {
+                    // These error codes are returned if the Python interpreter is a corrupt MSIX
+                    // package, which we want to differentiate from a typical spawn failure.
+                    #[cfg(windows)]
+                    Some(APPMODEL_ERROR_NO_PACKAGE | ERROR_CANT_ACCESS_FILE) => {
+                        Error::CorruptWindowsPackage {
+                            path: interpreter.to_path_buf(),
+                            err,
+                        }
+                    }
+                    _ => Error::SpawnFailed {
+                        path: interpreter.to_path_buf(),
+                        err,
+                    },
+                },
+            )?;
 
         if !output.status.success() {
             let stderr = String::from_utf8_lossy(&output.stderr).trim().to_string();