diff --git a/crates/uv/src/cli.rs b/crates/uv/src/cli.rs
index 3d103b86a..1987445b1 100644
--- a/crates/uv/src/cli.rs
+++ b/crates/uv/src/cli.rs
@@ -1641,6 +1641,11 @@ pub(crate) struct RunArgs {
     /// Run with the given packages installed.
     #[arg(long)]
     pub(crate) with: Vec<String>,
+
+    /// Run without the current workspace installed.
+    #[arg(long)]
+    pub(crate) no_workspace: bool,
+    // TODO(zanieb): Consider alternative names like `--no-project` or `--without-project`
 }
 
 #[derive(Args)]
diff --git a/crates/uv/src/commands/run.rs b/crates/uv/src/commands/run.rs
index ed6f40562..3c4e43b9c 100644
--- a/crates/uv/src/commands/run.rs
+++ b/crates/uv/src/commands/run.rs
@@ -43,6 +43,7 @@ pub(crate) async fn run(
     args: Vec<String>,
     mut requirements: Vec<RequirementsSource>,
     isolated: bool,
+    no_workspace: bool,
     cache: &Cache,
     printer: Printer,
 ) -> Result<ExitStatus> {
@@ -52,9 +53,10 @@ pub(crate) async fn run(
     // cannot be applied to transitive dependencies.
     let overrides = requirements.clone();
 
-    // TODO(zanieb): Provide an opt-out for this behavior
-    if let Some(workspace_requirements) = find_workspace_requirements()? {
-        requirements.extend(workspace_requirements);
+    if !no_workspace {
+        if let Some(workspace_requirements) = find_workspace_requirements()? {
+            requirements.extend(workspace_requirements);
+        }
     }
 
     // Detect the current Python interpreter.
diff --git a/crates/uv/src/main.rs b/crates/uv/src/main.rs
index b562a5735..bfc373ef7 100644
--- a/crates/uv/src/main.rs
+++ b/crates/uv/src/main.rs
@@ -599,6 +599,7 @@ async fn run() -> Result<ExitStatus> {
                 args.args,
                 requirements,
                 args.isolated,
+                args.no_workspace,
                 &cache,
                 printer,
             )