diff --git a/crates/uv-cli/src/lib.rs b/crates/uv-cli/src/lib.rs
index e9ae8243d..7bcce8dcd 100644
--- a/crates/uv-cli/src/lib.rs
+++ b/crates/uv-cli/src/lib.rs
@@ -1608,7 +1608,7 @@ pub struct PipCompileArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`.
     /// Clear previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub no_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// Only use pre-built wheels; don't build source distributions.
@@ -1619,7 +1619,7 @@ pub struct PipCompileArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`.
     /// Clear previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub only_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// The Python version to use for resolution.
@@ -1969,7 +1969,7 @@ pub struct PipSyncArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`. Clear
     /// previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub no_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// Only use pre-built wheels; don't build source distributions.
@@ -1980,7 +1980,7 @@ pub struct PipSyncArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`. Clear
     /// previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub only_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// Allow sync of empty requirements, which will clear the environment of all packages.
@@ -2346,7 +2346,7 @@ pub struct PipInstallArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`. Clear
     /// previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub no_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// Only use pre-built wheels; don't build source distributions.
@@ -2357,7 +2357,7 @@ pub struct PipInstallArgs {
     ///
     /// Multiple packages may be provided. Disable binaries for all packages with `:all:`. Clear
     /// previously specified packages with `:none:`.
-    #[arg(long, conflicts_with = "no_build")]
+    #[arg(long, value_delimiter = ',', conflicts_with = "no_build")]
     pub only_binary: Option<Vec<PackageNameSpecifier>>,
 
     /// The minimum Python version that should be supported by the requirements (e.g., `3.7` or
diff --git a/crates/uv/tests/it/pip_install.rs b/crates/uv/tests/it/pip_install.rs
index e7129c40b..55339586e 100644
--- a/crates/uv/tests/it/pip_install.rs
+++ b/crates/uv/tests/it/pip_install.rs
@@ -2765,6 +2765,37 @@ fn install_no_binary_overrides_only_binary_all() {
     context.assert_command("import anyio").success();
 }
 
+/// Accept comma-separated values for `--no-binary` (pip compatibility)
+#[test]
+fn install_no_binary_comma_separated() {
+    let context = TestContext::new("3.12");
+
+    // Use comma-separated format for `--no-binary`
+    let mut command = context.pip_install();
+    command
+        .arg("anyio")
+        .arg("--no-binary=idna,sniffio")
+        .arg("--strict");
+    uv_snapshot!(
+        command,
+        @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 3 packages in [TIME]
+    Prepared 3 packages in [TIME]
+    Installed 3 packages in [TIME]
+     + anyio==4.3.0
+     + idna==3.6
+     + sniffio==1.3.1
+    "###
+    );
+
+    context.assert_command("import anyio").success();
+}
+
 /// Disable binaries with an environment variable
 /// TODO(zanieb): This is not yet implemented
 #[test]
@@ -2876,6 +2907,37 @@ fn install_only_binary_overrides_no_binary_all() {
     context.assert_command("import anyio").success();
 }
 
+/// Accept comma-separated values for `--only-binary` (pip compatibility)
+#[test]
+fn install_only_binary_comma_separated() {
+    let context = TestContext::new("3.12");
+
+    // Use comma-separated format for `--only-binary`
+    let mut command = context.pip_install();
+    command
+        .arg("anyio")
+        .arg("--only-binary=idna,sniffio")
+        .arg("--strict");
+    uv_snapshot!(
+        command,
+        @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 3 packages in [TIME]
+    Prepared 3 packages in [TIME]
+    Installed 3 packages in [TIME]
+     + anyio==4.3.0
+     + idna==3.6
+     + sniffio==1.3.1
+    "###
+    );
+
+    context.assert_command("import anyio").success();
+}
+
 /// Overlapping usage of `--no-binary` and `--only-binary`
 // TODO(zanieb): We should have a better error message here
 #[test]